Renin release with carotid occlusion in the conscious dog: role of renal arterial pressure

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Abstract
The effect of carotid hypotension on renin release was evaluated with and without maintenance of normal renal perfusion pressure in conscious dogs. After unilateral nephrectomy, catheters were implanted in the aorta, vena cava and renal artery distal to an inflatable renal artery cuff. Bilateral carotid loops were prepared and the distal carotid artery was catheterized. On each dog bilateral carotid artery occlusion was performed for 20 min and renal arterial pressure allowed to rise and after a 30 min control period, carotid occlusion was repeated while renal arterial pressure was maintained at control levels by inflation of the renal cuff. Plasma renin activity (PRA) was determined before and after each of the two 20 min carotid occlusions. Experiments were performed on 4 consecutive days in each dog while they were on a diet with 10 (low Na) or 70 meq/day of Na (normal). No significant change in PRA was associated with carotid occlusion regardless of salt state when renal artery pressure was allowed to rise with systemic pressure. When renal perfusion pressure was maintained at control level, carotid occlusion resulted in a significant rise in PRA (normal Na diet .DELTA.PRA = 0.6 .+-. 0.1 ng/ml .cntdot. h, P < 0.01; low Na .DELTA.PRA = 2.9 .+-. 0.5 ng/ml .cntdot. h, P < 0.001). Carotid hypotension induces a rise in PRA provided renal perfusion pressure is maintained at control level.

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