Transcription of the Genome of Adenovirus Type 12
- 1 October 1975
- journal article
- Published by Wiley in European Journal of Biochemistry
- Vol. 58 (2) , 283-290
- https://doi.org/10.1111/j.1432-1033.1975.tb02374.x
Abstract
In human KB cells productively infected with adenovirus type 12, viral DNA replication starts between 12 and 14h postinfection. Virus-specific, polysome-associated mRNA was investigated early (6-8h) and late (26-28h) after infection. Most of the viral mRNA was polyadenylated and accounted for 0.46% and 24.1% of the mRNA synthesized early and late postinfection, respectively. The viral-specific mRNA isolated both early and late after infection falls into several distinct size-classes, ranging in molecular weights between 0.3X10(6) and 1.5X10(6) for the early RNA and between 0.6X10(6) and 2.3X10(6) for the RNA synthesized late in the infection.Keywords
This publication has 39 references indexed in Scilit:
- Viral DNA in transformed cells: I. A study of the sequences of adenovirus 2 DNA in a line of transformed rat cells using specific fragments of the viral genomeJournal of Molecular Biology, 1974
- Integration of Adenovirus DNA into the Cellular GenomePublished by Cold Spring Harbor Laboratory ,1974
- RNA Synthesis and Processing in Adenovirus-infected CellsCold Spring Harbor Symposia on Quantitative Biology, 1974
- Synthesis of viral components in hybrids of differentially permissive cells infected with adenovirus Type 12Experimental Cell Research, 1972
- Temperature-sensitive mutants of human adenovirus type 12Virology, 1971
- Adenovirus DNAJournal of Molecular Biology, 1971
- The response of BHK21 cells to infection with type 12 adenovirusArchiv für die gesamte Virusforschung, 1970
- Molecular weights of some HeLa ribosomal RNA'sJournal of Molecular Biology, 1969
- Adenovirus Tumorigenesis: Role of the Viral Genome in Determining Tumor MorphologyScience, 1967
- A membrane-filter technique for the detection of complementary DNABiochemical and Biophysical Research Communications, 1966