MINOR HEMOGLOBIN FRACTIONS IN UREMIC AND IN DIABETIC-PATIENTS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 7  (2) , 109-114
Abstract
Using a high resolution automated chromatographic method, the levels of the different minor Hb A1a, A1b and A1c were measured in 20 healthy controls, in 20 patients with chronic renal failure, in 20 uremic patients on intermittent hemodialysis, and in 20 insulin-dependent diabetic patients. In uremic non-hemodialyzed patients, the levels of the 3 minor fractions were increased significantly. The 2 fractions Hb A1b and A1c were normalized subsequent to hemodialysis; the level of Hb A1a was higher in the hemodialyzed than in the uremic non-hemodialyzed group. In both groups of uremic patients, no corelation was found between the minor Hb fractions and the corresponding serum creatinine, uric acid, urea, P, bicarbonate and blood glucose levels. In diabetic patients, the 3 minor fractions were increased. As expected, Hb A1c and glucose concentrations were tightly correlated. No correlation was found between blood glucose levels and Hb A1a; a correlation existed between blood glucose levels and Hb A1b. The increase of minor Hb fractions in renal failure does not only reflect the glucose intolerance. Renal failure itself causes an increase of the 3 minor fractions. Overall assay of the minor Hb components (Hb A1) may lead to misinterpretation in case of diabetic patients with chronic renal failure.

This publication has 3 references indexed in Scilit: