Effect of synthetic enantiomeric cannabinoids on platelet aggregation

1 October 1992

journal article
Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology

Vol. 70 (10) , 1305-1308
https://doi.org/10.1139/y92-182

Abstract

The effect of a synthetic pair of enantiomeric cannabinoids on platelet function was evaluated. The nonpsychotropic enantiomer, the 1,1-dimethylheptyl homolog of (+)-(3S,4S)-7-hydroxy-Δ-6-tetrahydrocannabinol (HU-211), was found to be more active in inhibiting ADP-induced platelet aggregation than the highly psychotropic (−)-enantiomer (HU-210). The related (+)-(3R,4R) cannabinoid, HU-213, which lacks the 7-hydroxy moiety, exerted its inhibitory effect within a wider range of concentrations. The results indicate a differentiation between psychotropic activity and inhibition of platelet aggregation in the cannabinoid group of compounds.Key words: enantiomeric cannabinoids, platelet aggregation.

Keywords

This publication has 0 references indexed in Scilit: