Paradoxical Sleep Rebound Without Previous Debt: The Effect of Minute Doses of Clonidine in Man
Open Access
- 1 September 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Sleep
- Vol. 6 (1) , 60-66
- https://doi.org/10.1093/sleep/6.1.60
Abstract
This report describes an experimental condition in which clonidine administration does not modify paradoxical sleep (PS) directly, but is followed by a secondary rebound, After oral consumption of minute doses of clonidine (CLN), 12 subjects showed no direct effect of CLN, but showed a significant increase of PS production in the following placebo night. Four other subjects experienced a decrease of PS under CLN and no rebound the next night. In addition, these four subjects had mechanisms of slow wave sleep production significantly weaker than the first 12 subjects.Keywords
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