Growth Hormone and Thyroxine: Effects on Submaxillary Gland of Hypophysectomized Rat.

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Abstract
Submaxil-lary glands of hypophysectomized male albino rats injected with growth hormone and thyroxine, both alone and in combination, were studied. Growth hormone and thyroxine separately were only partially effective in preventing hypophysectomy-induced enzymatic and histologic changes in the submaxillary gland. The 2 hormones together, however, maintained normal histologic appearance and enzymatic activity. Administration of either growth hormone or thyroxine alone to hypophysectomized rats did not maintain normal concentration and distribution of ribonucleic acid in the submaxillary gland, stomach or pancreas. The 2 hormones together were completely effective in maintaining normal ribonucleic acid (RNA) concentration and distribution.