The protein encoded by the functional steroid receptor RNA activator is a new modulator of ER alpha transcriptional activity

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Abstract
The steroid receptor RNA activator gene (SRA1) encodes for a functional RNA (SRA) as well as a protein (SRAP). While several groups reported on SRA-RNA mechanism of action, SRAP exact function remains to be elucidated, mainly due to a lack of studies investigating the function of the protein independently of its RNA counterpart. Using two independent models to examine its specific functions, SRAP was found to enhance estrogen receptor alpha activity in a ligand and response-element dependent manner. Our data therefore suggest that both transcript and protein products of the SRA1 gene co-modulate the transcriptional activity of steroid receptors.
Funding Information
  • the Canadian Institute of Health Research (CIHR)
  • the CancerCare Manitoba Foundation (CCMF)
  • the Manitoba Health Research Council (MHRC)
  • the Canadian Breast Cancer Foundation (CBCF)
  • National Science and Engineering Research Council of Canada (NSERC)