Vitamin E and selenium regulate balance between β-adrenergic and muscarinic responses in rat lungs
- 20 June 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 233 (2) , 427-431
- https://doi.org/10.1016/0014-5793(88)80476-9
Abstract
The effects of hydrogen peroxide on the β-adrenergic and muscarinic responses of the rat trachea muscle were studied in vitro, after feeding rats, for 6 weeks, either a diet deficient in vitamin E and selenium or a control diet. In the control situation after incubation with 1 mM hydrogen peroxide for 30 min, a reduction of the maximal response to methacholine of 39% occurred whereas no pD2 shift could be demonstrated. Moreover, no response to isoprenaline after precontraction with 3 × 10−7 M methacholine was left. In the deficient situation, we found a reduction to 64% of the response to methacholine after incubation with 1 mM hydrogen peroxide. Again isoprenaline became inactive, i.e. no relaxation with isoprenaline was observed after precontraction with 3 × 10−7 M methacholine. We therefore conclude that vitamin E and selenium protect against oxidative stress in lung tissue and thus regulate the (patho-) physiological balance between adrenergic and muscarinic responsesKeywords
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