Poiseuille flow method for measuring cell-to-cell adhesion
- 1 April 1986
- journal article
- Published by Springer Nature in Cell Biochemistry and Biophysics
- Vol. 8 (2) , 119-130
- https://doi.org/10.1007/bf02788476
Abstract
A theoretical description of the cell aggregation process in the Poisseuille flow is presented, the capture efficiency being used as the measure of cell adhesiveness. The value of this coefficient is determined both for nonspecific and specific (i.e., mediated by molecules) cell-to-cell interactions. Regarding the cell adhesion described by the DLVO theory, it is possible to determine the conditions under which cell adhesion is maximal. The dependence of capture efficiency on parameters such as shear rate, size of cell, surface potential of cell, the Hamaker constant of substances constituting the cell membrane, and composition of the medium is analyzed.Keywords
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