Beitrag zur Synthese von Dipeptiden, in denen Serin die Aminogruppe aufweist.
- 1 January 1935
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 234 (4-5) , 181-195
- https://doi.org/10.1515/bchm2.1935.234.4-5.181
Abstract
N-acyl serines were hydrolyzed by acid with unusual ease. This fact was utilized in the preparation of dl-seryl dl-leucine through the following intermediates: dl-[alpha]-bromoisocaproyl dl-serine, dl-leucyl dl-mrine, dl-leucyl dl-seryl ethyl ester, dl-leucyl dl-seryl anhydride, dl-seryl dl-leucine. The last reaction took place with good yields in 10% H2SO4 at 37[degree] in 4 days. The general applicability of this method for the preparation of seryl dipeptides was illustrated by the preparation of dl-seryl glycine, dl-seryl Z-tyrosine, and l-seryl l-tyrosine.This publication has 0 references indexed in Scilit: