THE INFLUENCE OF VARIOUS POISONS ON THE MOVEMENT OF CHLORIDE AGAINST CONCENTRATION GRADIENTS FROM INTESTINE TO PLASMA

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Abstract
The chloride-impoverishment observed in preparations of the intestine of the dog (or cat) in the presence of sulphate or other indiffusible ions is abolished by adequate concns. of Na arsenite, NaF, H2S, HgCl2 and NaCN. With such poisoning chloride moves into the intestine and an outward movement of the indiffusible salt occurs. The chloride impoverishment apparently results from a relative impermeability of the normal intestine to polyvalent anions. A further resemblance of the phenomena of chloride impoverishment by the intestine and that occurring in the kidney tubules is made apparent by the presence in urine of large amts. of these indiffusible salts, namely, sulphate and phosphate, and the loss of the ability of the kidney to dilute chloride when the ability to concentrate these indiffusible salts is lost through the action of some poison.

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