Increased pharyngeal bacterial colonization during viral illness

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Abstract
The oropharyngeal colonization by Staphylococcus aureus and Gram-negative bacilli (GNB) and its duration were studied in 89 house staff officers with biweekly quantitative cultures for 11 mo. Eightly-two episodes of upper respiratory tract infection were documented during the study period. The oropharyngal colonization during illness-free periods ranged from 12% to 18% for GNB and from 5% to 14% for S. aureus. During an episode of upper respiratory tract infection, the oropharyngeal colonization of GNB increased to 60%; S. aureus colonization increased to 43%. Colonization with GNB and S. aureus was transient and lasted for .apprx. 2 wk. The increased colonization by S. aureus and GNB during a viral respiratory tract infection may be a factor contributing to the increased risk of pneumonia in patients with this condition.