Effect of Antineoplastic Drugs on Cell Proliferation - Individually and in Combination

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Abstract
Three antineoplastic agents, bleomycin, cytosine arabinoside and 5-fluorouracil, were studied individually and in combination to determine their effectiveness in controlling cell growth in the presence of fetal bovine serum. All 3 drugs were effective individually in specifically controlling proliferation (as measured by 3H-thymidine uptake) of human Tenon''s capsule fibroblasts while bleomycin is effective at the lowest concentration. However, bleomycin alone rather than in combination with cytosine arabinoside or 5-fluorouracil was most effective in preventing division by these fibroblasts.