Cannabinoids and PPARα signalling
- 25 October 2006
- journal article
- conference paper
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 34 (6) , 1095-1097
- https://doi.org/10.1042/bst0341095
Abstract
Cannabinoids have been shown to possess anti-inflammatory and neuroprotective properties, which were proposed to occur mainly via activation of the G-protein-coupled receptor CB1 (cannabinoid receptor 1). Recently, certain cannabinoids have been reported to be ligands for members of the nuclear receptor transcription factor superfamily known as PPARs (peroxisome-proliferator-activated receptors). This review summarizes the evidence for cannabinoid activation of PPARs and identifies a new intracellular target for cannabinoids as therapeutic agents for neuroprotective treatment.Keywords
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