Placebo-Controlled Trial of Terlipressin (Glypressin) in the Management of Acute Variceal Bleeding
- 1 February 1989
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Journal of Clinical Gastroenterology
- Vol. 11 (1) , 58-60
- https://doi.org/10.1097/00004836-198902000-00014
Abstract
In a double-blind trial 60% of acute variceal bleeding episodes were controlled with terlipressin (glypressin) compared with 37% in patients given placebo (NS). Rebleeding was more common in the placebo group so that at 5 days bleeding remained under control in 54% of patients treated with terlipressin compared with only 19% after placebo therapy (p less than 0.025). Blood transfusion requirements were similar in the two groups. Terlipressin appeared to be the most effective in those patients with severe hepatic dysfunction.Keywords
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