Conformational Diffusion and Helix Formation Kinetics
- 18 September 2000
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 85 (12) , 2637-2640
- https://doi.org/10.1103/physrevlett.85.2637
Abstract
The time, temperature, and sequence dependences of helix formation kinetics of fully atomistic peptide models in explicit solvent are described quantitatively by a diffusive search within the coil state with barrierless transitions into the helical state. Conformational diffusion leads to nonexponential kinetics and jump-width dependences in temperature jump experiments.Keywords
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