Characterisation of Cyclosporine-Induced Suppressor Cells in Murine Delayed-Type Hypersensitivity Responses
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 79 (2) , 215-219
- https://doi.org/10.1159/000233974
Abstract
The effect of Cyclosporine A (CsA) on T cell-mediated delayed-type hypersensitivity (DTH) reactions to murine alloantigens was analysed by transferring spleen cells from sensitised and suppressed mice into irradiated naive recipients. Selective removal of Thy1+, Ly1+ or Ly2+ cells prior to intravenous transfer of cells from alloantigen-sensitised mice showed that Ly1+ Thy1+ cells transferred sensitivity. Concomitant treatment of mice with alloantigen and CsA suppressed the DTH response to alloantigens, and spleen cells transferred from these suppressed mice abrogated the response of sensitised cells transferred at the same time. The suppressor cells were strain-restricted and antigen-specific with the surface phenotype Thy + , Ly1–– Ly2+.Keywords
This publication has 18 references indexed in Scilit:
- EFFECT OF CYCLOSPORIN-A ON HUMAN-LYMPHOCYTE RESPONSES INVITRO .4. PRODUCTION OF T-CELL STIMULATORY GROWTH-FACTORS AND DEVELOPMENT OF RESPONSIVENESS TO THESE GROWTH-FACTORS IN CSA-TREATED PRIMARY MLR CULTURES1982
- Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection.The Journal of Experimental Medicine, 1981
- Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2European Journal of Immunology, 1981
- EFFECT OF CYCLOSPORIN A UPON SECOND-SET REJECTION OF RAT RENAL ALLOGRAFTSTransplantation, 1980
- Delayed-type hypersensitivity to allogeneic cells in mice. III. Sensitivity to cell-surface antigens coded by the major histocompatibility complex and by other genes.The Journal of Experimental Medicine, 1979
- Delayed Type Hypersensitivity to Allogeneic Cells in MiceInternational Archives of Allergy and Immunology, 1979
- Delayed Type Hypersensitivity to Allogeneic Cells in MiceInternational Archives of Allergy and Immunology, 1979
- T cell‐dependent suppression of antibody production. I. Characteristics of suppressor T cells following tolerance inductionEuropean Journal of Immunology, 1978
- EFFECTS OF NEW ANTI-LYMPHOCYTIC PEPTIDE CYCLOSPORIN-A IN ANIMALS1977
- Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.The Journal of Experimental Medicine, 1976