Thyroid Hormone Action: A Cell-Culture System Responsive to Physiological Concentrations of Thyroid Hormones
- 28 September 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 181 (4106) , 1253-1256
- https://doi.org/10.1126/science.181.4106.1253
Abstract
Cells from a rat pituitary tumor cell line will respond in vitro to physiological concentrations of L-thyroxine and L-triiodothyronine. The cells are grown in a cultutre medium that contains serum from a hypothyroid calf. Dose-response relationships of a vacriety of thyronine derivatives indicate that this system has a specificity of response which is similar to that observed in vitro.Keywords
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