Synthesis of antibacterial pen-2-em-3-carboxylic acids from clavulanic acid
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 663-664
- https://doi.org/10.1039/c39790000663
Abstract
The antibacterially active potassium salt (7b) has been synthesised from clavulanic acid (1a) by two routes involving either base-catalysed or thermolytic cyclisations of novel monocyclic azetidinones; protection of the hydroxy group of clavulanic acid followed by an analogous thermolytic cyclisation gave the corresponding 2-hydroxyethylpen-2-em ester (7d) from which a series of antibacterially active O-substituted derivatives was available.Keywords
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