Tuberculosis vaccines
Open Access
- 1 July 2002
- journal article
- review article
- Published by Oxford University Press (OUP) in British Medical Bulletin
- Vol. 62 (1) , 73-86
- https://doi.org/10.1093/bmb/62.1.73
Abstract
The increasing incidence of disease associated with HIV infection highlights the crucial role of the immune response in susceptibility to tuberculosis and has stimulated renewed efforts to develop improved vaccines. Vaccine targets include prevention of infection in naive individuals, prevention of re-activation in individuals harbouring latent infection, and prevention of relapse by immunotherapy in tuberculosis patients. Advances in mycobacterial molecular genetics have facilitated development of a range of live attenuated and subunit vaccine candidates that have been screened in experimental models of infection. Evaluation of the immunogenicity of selected candidate vaccines in clinical trials should be combined with a continuation of fundamental research on the immune response to mycobacterial infection and persistence.Keywords
This publication has 42 references indexed in Scilit:
- Enhanced Antimycobacterial Response to RecombinantMycobacterium bovisBCG Expressing Latency-Associated PeptideInfection and Immunity, 2001
- Failure to induce enhanced protection against tuberculosis by increasing T‐cell‐dependent interferon‐γ generationImmunology, 2001
- Patterns and Implications of Naturally Acquired Immune Responses to Environmental and Tuberculous Mycobacterial Antigens in Northern MalawiThe Journal of Infectious Diseases, 2001
- Protection of Mice with a Tuberculosis Subunit Vaccine Based on a Fusion Protein of Antigen 85B and ESAT-6Infection and Immunity, 2001
- Immunology of TuberculosisAnnual Review of Immunology, 2001
- Enhanced Immunogenicity of CD4+T-Cell Responses and Protective Efficacy of a DNA-Modified Vaccinia Virus Ankara Prime-Boost Vaccination Regimen for Murine TuberculosisInfection and Immunity, 2001
- Routine vaccinations and child survival: follow up study in Guinea-Bissau, West Africa Commentary: an unexpected finding that needs confirmation or rejectionBMJ, 2000
- Identification of a Mycobacterium bovis BCG Auxotrophic Mutant That Protects Guinea Pigs against M. bovis and Hematogenous Spread of Mycobacterium tuberculosis without Sensitization to TuberculinInfection and Immunity, 2000
- Simple, Practical Ways to Assess the Protective Efficacy of a New Tuberculosis VaccineClinical Infectious Diseases, 2000
- Expression Cloning of an Immunodominant Family of Mycobacterium tuberculosis Antigens Using Human Cd4+ T CellsThe Journal of Experimental Medicine, 2000