Pharmacodynamic Interaction of Doxycycline and Artemisinin in Plasmodium falciparum
Open Access
- 1 January 2002
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (1) , 262-264
- https://doi.org/10.1128/aac.46.1.262-264.2002
Abstract
Parallel in vitro tests, assessing the inhibition of schizont maturation, were conducted with 31 fresh isolates of Plasmodium falciparum from Thailand, using artemisinin, doxycycline, and combinations of both. The activities of artemisinin and doxycycline are obviously not correlated. Both compounds showed consistent synergism at 50% effective concentration (EC 50 ), EC 90 , and EC 99 levels.Keywords
This publication has 20 references indexed in Scilit:
- WHO Expert Committee on Malaria.2000
- Entomological and epidemiological investigations of malaria transmission in relation to population movements in forest areas of north-west Thailand.1998
- Efficacy of artemisinin and mefloquine combinations against Plasmodium falciparum. In vitro simulation of in vivo pharmacokineticsTropical Medicine & International Health, 1997
- Efficacy of artemisinin and mefloquine combinations againstPlasmodium falciparum. In vitrosimulation ofin vivopharmacokineticsTropical Medicine & International Health, 1997
- The sensitivity of Plasmodium protein synthesis to prokaryotic ribosomal inhibitorsMolecular and Biochemical Parasitology, 1997
- Interaction of artemisinin and tetracycline or erythromycin againstPlasmodium falciparum in vitroParasite, 1994
- Epidemiology of drug resistance in malariaActa Tropica, 1994
- Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu)Antimicrobial Agents and Chemotherapy, 1993
- Mefloquine-resistant falciparum malaria on the Thai-Burmese borderThe Lancet, 1991
- The dynamics of drug resistance in Plasmodium falciparumPharmacology & Therapeutics, 1991