Non‐cross‐reactivity of antibodies to murine LDH‐C4 with LDH‐A4 and LDH‐B4
- 1 December 1986
- journal article
- research article
- Published by Wiley in Journal of Experimental Zoology
- Vol. 240 (3) , 377-384
- https://doi.org/10.1002/jez.1402400312
Abstract
The induction of infertility by immunization with the sperm-specific lactate dehydrogenase, LDH-C4, suggests its use in a contraceptive vaccine. Development of an immunological contraceptive for human use, however, requires that there be no cross-reactions with somatic tissues. We have demonstrated, using enzyme-linked immunoabsorbence, solid-phase radioimmunoassay, and competitive inhibition radioimmunoassay, that antisera to LDH-C4 is specific and does not cross-react with the somatic isozymes, LDH-A4 and LDH-B4.This publication has 23 references indexed in Scilit:
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