Studies of energy-linked reactions. Net synthesis of adenosine triphosphate by isolated adenosine triphosphate synthase preparations: a role for lipoic acid and unsaturated fatty acids

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Abstract
ATP synthase [heart mitochondria] preparations [Complex V, proton-translocating ATPase and oligomycin-sensitive ATPase] contain stoicheiometric amounts of lipoic acid residues (up to 6 mol of lipoic acid/mol of ATPase complex) and catalyze net ATP synthesis in an uncoupler- and oligomycin-sensitive reaction utilizing dihydrolipoate, oleoyl-CoA and oleic acid, or in a reaction utilizing oleoyl-S-lipoate. The terminal reactions of oxidative phosphorylation are thus analogous to those of substrate-level phosphorylation.