CHRONIC MYELODYSPLASTIC SYNDROME (PRELEUKEMIA) WITH THE PHILADELPHIA-CHROMOSOME

Google Scholar
  • 1 January 1980
    • journal article
    • research article
    • Vol. 56  (2) , 262-264
Abstract
A patient with severe anemia, reticulocytopenia and erythroid hyperplasia of the bone marrow developed fatal acute nonlymphocytic leukemia after 3 yr. A Philadelphia chromosome with the typical 9/22 translocation t(9q+;22q-) was identified by banding techniques in a small number of bone marrow cells throughout the preleukemic phase of the illness (14-38% of metaphases) and during the acute transformation (50%). Granulocytic colony formation in vitro was abnormal in the preleukemic phase. The diagnosis of chronic chromosome in this form of chronic myelodysplastic syndrome (preleukemia) provides a new example of a hematologic disorder predisposing to acute leukemia in which this chromosomal abnormality occurs.