Experimental Studies of the Antitumor Effect of TNP-470 on Malignant Brain Tumors. Antitumor Effect of TNP-470 on a Human Medulloblastoma Xenograft Line

Publisher Website
Google Scholar
Abstract
It has been shown that angiogenesis plays an important role in pathological conditions including the growth of solid tumors. Furthermore, it is thought that anti-angiogenic agents might be clinically useful for therapy of these diseases. TNP-470 (TNP), a synthetic analog of fumagillin isolated from Aspergillus fumigatus, was used as an anti-angiogenic agent in this study in a nude mouse model with a subcutaneously implanted fragment of medulloblastoma. After treatment with this agent for 4 weeks, the inhibition rates of tumor growth were as follows: 15.9 % in the group given 1 mg/kg, 16.9 % with 10 mg/kg, 29.6 % with 30 mg/kg, 49.9 % with 50 mg/kg and 65.7 % with 100 mg/kg. TNP inhibited the growth of brain tumor dose-dependently and induced various ischemic changes within the tumor tissue. Therefore, TNP may be effective for the treatment of malignant brain tumors such as medulloblastoma.

This publication has 0 references indexed in Scilit: