Observations sur les activités anti-bactériennes in vitro des rifamycines B et SV

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Abstract
Gram-positive microorganisms (Staphylococcus pyogenes, Streptococcus pneumoniae, Streptococcus pyogenes, streptococci of the viridans group, non-hemolytic streptococci and Bacillus spp.) are more sensitive to rifamycins-B and -SV. The influence of inoculum size and age and of the duration of incubation before reading the results, can explain the differences observed. Gram-negative microorganisms (Salmonella typhosa, Salmonella schottmuelleri, Salmonella typhimurium and Salmonella spp.) were much less sensitive, although the growth of certain strains is inhibited by concentrations possible in vivo. Rifamycin-SV was usually from 2-5 times more active than rifamycin-B. The activity of these two antibiotics does not differ when the strains are sensitive or resistant to the usual antibiotics. The analysis of a staphylococcal population (S. pyogenes, H strain) indicated the existence of individuals with different degrees of resistance.