Herpes-Like DNA Sequences, AIDS-Related Tumors, and Castleman's Disease

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Abstract
An apparently new human herpesvirus, designated Kaposi's sarcoma–associated herpesvirus (KSHV) or human herpesvirus 8, has recently been identified in samples of Kaposi's sarcoma from patients infected with the human immunodeficiency virus (HIV).1 In the May 4 issue of the Journal, Moore and Chang2 reported finding KSHV DNA in samples of Kaposi's sarcoma from patients without HIV infection, and Cesarman et al.3 described finding KSHV DNA in an unusual high-grade body-cavity–based lymphoma in HIV-infected patients. The lymphoma shows a strong tendency toward primary involvement of body-cavity surfaces without local or distant spread to other viscera.4