Evidence for production of an inactive collagenase by fibroblasts from phenytoin‐enlarged human gingivae
- 1 July 1982
- journal article
- research article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 11 (4) , 310-317
- https://doi.org/10.1111/j.1600-0714.1982.tb00171.x
Abstract
When measured by radioimmunoassay, fibroblasts derived from the overgrown gingivae of phenytoin-treated epileptic individuals synthesize and release elevated amounts of collagenase in vitro, as compared to similar-appearing fibroblasts from normal, nonphenytoin-treated persons. However, it appears that much of the immunoreactive enzyme is unable to degrade reconstituted collagen in culture. This preliminary finding in 9 different strains of cells indicates that reduced collagenase activity by a subpopulation of cells may contribute to the development of phenytoin-induced gingival overgrowth.This publication has 29 references indexed in Scilit:
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