Renin, Sodium, and Vasodepressor Response to Saralasin in Renovascular and Essential Hypertension

Publisher Website
Google Scholar
Abstract
Saralasin (1-sar-8-ala-angiotensin II), a competitive inhibitor of angiotensin II, was administered to 32 patients with renovascular or essential hypertension before (day 1) and after (day 2) they were mildly Na-depleted by furosemide (1 mg/kg body wt). A blood pressure lowering effect of saralasin was observed in 16 of 17 patients with renovascular hypertension, on day 2, but in only 10 of the 17 on day 1. Of the 15 patients with essential hypertension, only the 4 with high renin levels exhibited a vasodepressor response on day 2; 3 responded similarly on day 1. The average net Na loss between the 2 days was greater for patients who responded to the drug on day 2 (170 meq) than those who did not (129 meq) (P < 0.05); there was no correlation between blood pressure response and either net Na loss or urinary Na excretion at the time of testing. Plasma renin activity correlated with saralasin responses (r = -0.74, P < 0.01). Saralasin testing during a state of modest Na-depletion compares favorably with renin measurements in the detection of renin-mediated hypertension.

This publication has 0 references indexed in Scilit: