Tumor Cytotoxicity of Human Macrophages After Incubation With Synthetic Analogues of 2-Lysophosphatidylcholine2
- 1 January 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 72 (1) , 53-59
- https://doi.org/10.1093/jnci/72.1.53
Abstract
Human alveolar macrophages as well as macrophages derived from Teflon culture of blood-borne monocytes were incubated with synthetic analogues of 2-lysophosphatidylcholine and then tested for their cytotoxic capacity against an allogeneic lymphoma cell line. Metabolic, rather stable analogues enhanced macrophage cytotoxicity significantly. This phenomenon was shown both in a growth-inhibition assay as well as in the 51 Cr release assay. Macrophage activation was dose- and time-dependent and was potentiated at temperatures above 37°C. Incubation of the macrophages with the active compounds induced characteristic changes in cell morphology as revealed by scanning electron microscopy.Keywords
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