Imidazo[1,2-b]Pyridazines. V. Syntheses and Central Nervous Activities of Some 3-Alkoxy-6-benzylthio(substituted benzylthio and Other phenylalkylthio)-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines

1 January 1989

journal article
research article
Published by CSIRO Publishing in Australian Journal of Chemistry

Vol. 42 (7) , 1133-1146
https://doi.org/10.1071/ch9891133

Abstract

Syntheses are reported for a number of 3-alkoxy-6-benzylthio(substituted benzylthio and other phenylakylthio)-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines. These compounds were then examined for their ability to displace 3H-diazepam from rat brain membranes. In preliminary tests, in the presence of 100 .mu.M .gamma.-aminobutyric acid (GABA) and under standard assay conditions (see Experimental), 6-benzylthio-3-methoxy-2-phenylimidazo[1,2-.beta.]pyridazine gave an IC50 value of 25 nM (IC50 for unlabelled diazepam is 4.3 nM); its 6-(m-aminophenyl), 6-(p-aminophenyl) and 6-(m-nitrophenyl) analogues gave values of 15, 9 and 8 nM respectively.

Keywords

This publication has 1 reference indexed in Scilit:

Imidazo[1,2-b]pyridazines. IV. Syntheses and Central Nervous System Activities of Some 3-Methoxy-6-phenoxy(Substituted Phenoxy and Naphthyloxy)-2-phenylimidazo[1,2-b]pyridazines
Australian Journal of Chemistry, 1988