Fetal Kidney in Organ Culture: Abnormalities of Development Induced by Decreased Amounts of Potassium
- 31 July 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 169 (3944) , 485-487
- https://doi.org/10.1126/science.169.3944.485
Abstract
Kidneys from fetal mice (10 to 18 days' gestation) were grown in organ culture. Concentrations of potassium less than 9 milliequivalents per liter (10- to 14-day kidneys), and less than 6 milliequivalents per liter (14- to 18-day kidneys), produced abnormal branching, failure of nephron induction, and occasional cystic dilatations of the ureteral bud. These studies emphasize the importance of an environment with a high concentration of potassium for development of the fetal kidney.Keywords
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