Luffin‐S—a small novel ribosome‐inactivating protein from Luffa cylindrica
- 27 June 1994
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 347 (2-3) , 257-260
- https://doi.org/10.1016/0014-5793(94)00554-0
Abstract
We purified and characterized a novel RIP (ribosome inactivating protein), Luffin-S from the seeds of Luffa cylindrica. Different from Luffin-A and B, which are RNA N-glycosidases with molecular weights of 27 and 28 kDa, respectively, Luffin-S has an M.W. of only approx. 10 kDa, much smaller than any other RIPs so far investigated. Its abundant resources, toxicity similar to TCS in a cell-free protein synthesis system and unique mechanism as phosphodiesterase, like α-sarcin, promisingly make it a potential toxic moiety of immunotoxin.Keywords
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