Interaction of Insulin with Small Intestinal Epithelial Cells from Developing Rats
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Neonatology
- Vol. 54 (5) , 289-293
- https://doi.org/10.1159/000242865
Abstract
The interaction of insulin with its specific receptors was studied in jejunoileal epithelial cells from 14-, 20-, and 60-day-old rats. Characteristics such as potency and specificity of the insulin receptor system did not vary during development. However, insulin binding decreased with age due to a diminished concentration of insulin receptors, whereas the circulating levels of the hormone followed an inverse evolution. These results support previous suggestions on the potential role of insulin on the mechanisms of differentiation and proliferation of small intestinal mucosa.Keywords
This publication has 7 references indexed in Scilit:
- Ontogeny of EGF Receptors During Postnatal Development of Mouse Small IntestineJournal of Pediatric Gastroenterology and Nutrition, 1987
- Insulin binding to rat intestinal epithelial cells following partial small-bowel resectionBioscience Reports, 1986
- Interaction of epidermal growth factor with specific binding sites of enterocytes isolated from rat small intestine during developmentBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1986
- Peptide binding to intestinal epithelium: Distinct sites for insulin, EGF and VIPPeptides, 1985
- Insulin receptors in the gastrointestinal tract of the rat fetus: quantitative autoradiographic studiesDiabetologia, 1985
- Quantitative studies of vasoactive intestinal peptide (VIP) binding sites and VIP-induced adenosine 3′:5′-monophosphate production in epithelial cells from duodenum, jejunum, ileum, coecum, colon and rectum in the ratActa Endocrinologica, 1981
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951