Amino acid sequences of the human kidney cathepsins H and L
- 15 February 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 228 (2) , 341-345
- https://doi.org/10.1016/0014-5793(88)80028-0
Abstract
The complete amino acid sequences of human kidney cathepsin H (EC 3.4.22.16) and human kidney cathepsin L (EC 3.4.22.15) were determined. Cathepsin H contains 230 residues and has an M r of 25 116. The sequence was obtained by sequencing the light, heavy and mini chain and the peptides produced by cyanogen bromide cleavage of the single-chain form of the enzyme. The glycosylated mini chain is a proteolytic fragment of the propeptide of cathepsin H. Human cathepsin L has 217 amino acid residues and an M r of 23720. Its amino acid sequence was deduced from N-terminal sequences of the heavy and light chains and from the sequences of cyanogen bromide fragments of the heavy chain. The fragments were aligned by comparison with known sequences of cathepsins H and L from other species. Cathepsins H and L exhibit a high degree of sequence homology to cathepsin B (EC 3.4.22.1) and other cysteine proteinases of the papain superfamily.Keywords
This publication has 19 references indexed in Scilit:
- Molecular cloning and sequencing of cDNA for rat cathepsin LFEBS Letters, 1987
- Purification and amino acid sequence of chicken liver cathepsin LBiochemistry, 1987
- Amino acid sequence of chicken liver cathepsin LEuropean Journal of Biochemistry, 1987
- Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.Proceedings of the National Academy of Sciences, 1986
- Solid-Phase Microsequencing: Procedures and Their Potential for Practical Sequence AnalysisPublished by Springer Nature ,1986
- Identification of cDNA clones encoding a precursor of rat liver cathepsin B.Proceedings of the National Academy of Sciences, 1985
- Amino acid sequence of human liver cathepsin BFEBS Letters, 1985
- Homology of amino acid sequences of rat liver cathepsins B and H with that of papain.Proceedings of the National Academy of Sciences, 1983
- [41] Cathepsin B, cathepsin H, and cathepsin LPublished by Elsevier ,1981
- The limited proteolysis of rabbit muscle aldolase by cathepsin B1Biochemical and Biophysical Research Communications, 1978