Anti-Inflammatory Active Polyacetylenes fromBidens campylotheca
- 1 February 1994
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 60 (01) , 58-62
- https://doi.org/10.1055/s-2006-959409
Abstract
The n-hexane extract of Bidens campylotheca Schultz Bip. ssp campylotheca (Compositae) showed significant in vitro inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO). Five polyacetylenes, heptadeca-2E,8E,10E,16-tetraene-4,6-diyne (1), heptadeca-2E,8Z,10E,16-tetraene-4,6-diyne (2), heptadeca-2E,8E,16-triene-4,6-diyne-10-ol (3), safynol (5) and, as a new Compound, safynol-2-O-isobutyrate (4) could be isolated and their structures elucidated mainly by UV, MS, NMR, and COSY-NMR. The isolated Compounds exhibited a significant inhibitory effect on cyclooxygenase and 5-lipoxygenase.Keywords
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