3D radial projection technique with ultrashort echo times for sodium MRI: Clinical applications in human brain and skeletal muscle
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Open Access
- 26 December 2006
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 57 (1) , 74-81
- https://doi.org/10.1002/mrm.21104
Abstract
23Na MRI has the potential to noninvasively detect sodium (Na) content changes in vivo. The goal of this study was to implement 23Na MRI in a clinical setting for neurooncological and muscular imaging. Due to the biexponential T2 decay of the tissue Na signal with a short component, which ranges between 0.5–8 ms, the measurement of total Na content requires imaging techniques with echo times (TEs) below 0.5 ms. A 3D radial pulse sequence with a TE of 0.2 ms at a spatial resolution of 4 × 4 × 4 mm3 was developed that allows the acquisition and presentation of Na images on the scanner. This sequence was evaluated in patients with low‐ and high‐grade gliomas, and higher 23Na MR signals corresponding to an increased Na content were found in the tumor regions. The contrast‐to‐noise ratio (CNR) between tumor and white matter increased from 0.8 ± 0.2 to 1.3 ± 0.3 with tumor grade. In patients with an identified muscular 23Na channelopathy (Paramyotonia congenita (PC)), induced muscle weakness led to a signal increase of ∼18% in the 23Na MR images, which was attributed to intracellular Na+ accumulation in this region. Magn Reson Med 57:74–81, 2007.Keywords
This publication has 27 references indexed in Scilit:
- ECG-gated 23 Na-MRI of the human heart using a 3D-radial projection technique with ultra-short echo timesMagnetic Resonance Materials in Physics, Biology and Medicine, 2004
- Noninvasive quantification of total sodium concentrations in acute reperfused myocardial infarction using 23Na MRIMagnetic Resonance in Medicine, 2001
- Theoretical basis for sodium and potassium MRI of the human heart at 1.5 TMagnetic Resonance in Medicine, 1997
- Three‐dimensional projection imaging with half the number of projectionsMagnetic Resonance in Medicine, 1997
- In vivo23Na NMR studies of myotonic dystrophyMagnetic Resonance in Medicine, 1997
- The gridding method for image reconstruction by Fourier transformationIEEE Transactions on Medical Imaging, 1995
- A comprehensive approach to the analysis and interpretation of the resonances of spins 3/2 from living systemsNMR in Biomedicine, 1991
- Selection of a convolution function for Fourier inversion using gridding (computerised tomography application)IEEE Transactions on Medical Imaging, 1991
- Detection of biexponential relaxation in sodium-23 facilitated by double-quantum filteringJournal of Magnetic Resonance (1969), 1986
- FLASH imaging. Rapid NMR imaging using low flip-angle pulsesJournal of Magnetic Resonance (1969), 1986