Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
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Open Access
- 28 July 2007
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 50 (12) , 2443-2450
- https://doi.org/10.1007/s00125-007-0753-6
Abstract
Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes and reduced insulin secretion. The transcription factor TCF7L2 is an essential factor for glucagon-like peptide-1 (GLP-1) secretion from intestinal L cells. We studied whether a defect in the enteroinsular axis contributes to impaired insulin secretion in carriers of TCF7L2 polymorphisms.Keywords
This publication has 28 references indexed in Scilit:
- Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian populationDiabetologia, 2006
- Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohortDiabetologia, 2006
- Common Single Nucleotide Polymorphisms in TCF7L2 Are Reproducibly Associated With Type 2 Diabetes and Reduce the Insulin Response to Glucose in Nondiabetic IndividualsDiabetes, 2006
- Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and MenDiabetes, 2006
- Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish SampleDiabetes, 2006
- Polymorphisms in the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in the AmishDiabetes, 2006
- TCF7L2Polymorphisms and Progression to Diabetes in the Diabetes Prevention ProgramNew England Journal of Medicine, 2006
- Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesNature Genetics, 2006
- Nucleotide Sensitivity of Pancreatic ATP-Sensitive Potassium Channels and Type 2 DiabetesDiabetes, 2002
- The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala PolymorphismDiabetes, 2002