The Spleen as a Site of Colony-Forming Cell Production in Myelofibrosis

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Abstract
Increased numbers of colony-forming cells (CFU-C) were found in peripheral blood of 11 patients with myelofibrosis. CFU-C determinations were performed on blood from the splenic vein and artery and peripheral blood of two of these patients at the time of splenectomy. There was a significantly greater concentration of CFU-C in the splenic venous blood as opposed to splenic arterial or peripheral blood. In a patient with pathologic stage IIA Hodgkin's disease, CFU-C concentrations in splenic venous and arterial blood were not statistically different and were similar to those in peripheral blood. These findings suggest that the spleen may be an important site of CFU-C production in some patients with myelofibrosis.

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