HUMAN LYMPHOKINE INVITRO PRODUCTION INDUCED BY A SPECIFIC MITOGEN (HOUSE DUST EXTRACT)

  • 1 January 1984
    • journal article
    • research article
    • Vol. 42  (3) , 207-210
Abstract
Concanavalin [con]A-stimulated lymphocytes from some patients with primary glomerular disease release in vitro a lymphokine, the vascular permeability factor (VPF). House dust sensitization was reported among these patients. The action of this specific mitogen of VPF production in 58 patients with primary glomerular disease, 23 were chosen because of cutaneous house dust sensitivity. For all patients, house dust and Con A-induced VPF production was statistically equivalent and both higher than that of unstimulated lymphocytes. Lymphocytes from the 23 house dust sensitized patients, stimulated by the allergen, produced more VPF than lymphocytes from unsensitized patients.