Absence of microsatellite instability during the progression of chronic myelocytic leukemia
- 1 January 1997
- journal article
- research article
- Published by Springer Nature in Leukemia
- Vol. 11 (1) , 151-152
- https://doi.org/10.1038/sj.leu.2400524
Abstract
Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed throughout the genome. To test the occurrence of genetic instability in the progression of chronic myelocytic leukemia (CML), we studied microsatellite instability (MSI) in 17 patients with CML. The DNAs from both chronic phase and blast crisis were analyzed at 10 loci. No MSI was observed in any of the 17 cases of blast crisis. These results indicate that MSI is rare and is not associated with progression to blast crisis in most cases of CML.Keywords
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