Quantification of serum IgE in patients with burns

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Abstract
Ig[immunoglobulin]E levels in the serum of individuals with burns were sequentially measured and compared to IgE levels in normal control blood donors. Following a burn, the levels of IgE protein showed a significant, small increase, usually evident between days 14-22. In an occasional patient the IgE levels rose by as much as 5 times in value during this period. Because of the complexity of the clinical situation associated with the burn patients, these elevations of IgE could not be ascribed to the burn per se but the possibility of other factors, especially those involved in the treatment of the burn and the infection must be considered. The magnitude of the elevation of IgE in the burn patients (geometric mean = 272 ng/ml) was considerably lower than the magnitude of the elevations seen in atopic dermatitis and generalized neurodermatitis (geometric means = 2265 and 2071 ng/ml, respectively). Simple trauma to the skin is not a sufficient explanation for the elevated serum IgE levels in atopic dermatitis and generalized neurodermatitis.

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