Reactive disulfide bonds in immunoglobulin G. A unique feature in serum proteins of different species
Open Access
- 1 October 1996
- journal article
- Published by Wiley in IUBMB Life
- Vol. 40 (3) , 433-446
- https://doi.org/10.1080/15216549600201003
Abstract
A reactive disulfide bond (SS)* was detected and characterized in IgG of humans, rats and mice by virtue of disulfide interchange with dithionitrobenzoate. (SS)* was found exclusively in human IgG1 and rat IgG2b. In human IgG1 (SS)* was identified as the upper one of the two interheavy bridges in the hinge, where it appears to take part in complement activation. The biological significance of (SS)* in IgG was underlined by the fact that no other serum proteins were found to exhibit a similar reactivity.Keywords
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