Fc- and Complement-Receptor Rosette-Forming Cell Ratios in Human Tonsils and Peripheral Blood

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Abstract
Lymphocytes were investigated for both Fc- and complement-rosette-forming cell activities. At least three subpopulations differing in the relative activities of the Fc and complement receptors have been disclosed. In human tonsils a subpopulation of B lymphocytes had a higher complement-receptor activity than Fc-receptor activity. In contrast, the peripheral cells from a patient with a lymphoma and another with an undiagnosed lymphocytic disease contained a population of B lymphocytes with higher Fc-receptor than complement-receptor activity. In three patients with chronic lymphocytic leukemia, B lymphocytes contained both Fc- and complement-receptor activities. No differences between complement- and Fc-receptor activities were evident in normal human peripheral blood. Fc-receptor, but not complement-receptor activity was inhibited by 2% γ-globulin, or 8 × 103 m iodoacetate. EDTA at 1.7 × 10-2 m concentration has no effect upon Fc- or complement-rosette-forming cells. The activity of both receptors was diminished at 4°C.

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