An Attenuated Influenza Virus Vaccine: Reactogenicity, Transmissibility, Immunogenicity, and Protective Efficacy

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Abstract
An attenuated influenza virus vaccine (not sensitive to equine serum) was administered intranasally by nose drops and was effective in stimulating significant rises in both serum and nasal antibody and in protecting against subsequent challenge with virulent influenza virus. Vaccine virus was not transmitted from immunized volunteers to a control group. Clinical symptoms after immunization were very mild but were significantly more frequent in vaccinees than in members of the control group.