The effect of crystal hardness on compaction propensity.

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Abstract
The effect of crystal hardness on the compaction mechanism and tensile strength of tablets was investigated by using twelve different materials. The tensile strength of tablets was found to be independent of crystal hardness. This result suggests that crystal hardness is not directly associated with the binding force between crystal particles, and this result can be ascribed to differences in the mode of crystal deformation, that is, fragmentation, plastic flow, etc. The reciprocal of crystal hardness was correlated to the K value in the Heckel equation for organic materials. Furthermore, at constant pressure there was a linear relationship between the reciprocal of crystal hardness and the logarithm of the reciprocal of fractional voidage.

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