Dihydrotestosterone-binding protein in cytosols of normal and hypertrophic human prostates, and influence of estrogens and anti-androgens on the binding.

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Abstract
Dihydrotestosterone-binding protein was observed in cytosols of normal and hypertrophic human prostates. The association constant Ka for dihydrotestosterone of cytosol of the normal prostate differed slightly from that of the hypertrophic prostate. Maximum binding capacity was almost identical in these tissues. No distinct correlation was detected between proportion of glandular constituent and binding characteristics (Ka and maximum binding capacity) in the hypertrophic prostates. The influence of some steroids on the binding with dihydrotestosterone was examined. Testosterone, estradiol-17.beta., estriol, cyproterone acetate and SK and F 7690 [Flutamide] inhibited the binding competitively. Sch 13521 [17.alpha.-methyl-.beta.-nortesterone] did not exhibit any influence on the binding.

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