5-Decynedioic Acid, an Acetylenic Compound in Human Urine
Open Access
- 1 December 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 21 (13) , 1964-1969
- https://doi.org/10.1093/clinchem/21.13.1964
Abstract
An acetylenic dicarboxylic acid, 5-decynedioic acid, has been isolated from human urine. The structure was determined by mass spectrometry of several derivatives, and by infrared spectroscopy. On osmium tetroxide oxidation, a vic-diketone was formed, the mass spectrum of which established the position of the triple bond between carbon atoms 5 and 6. Mass spectrometric evidence for the presence of a small amount of the isomeric 4-decynedioic acid was also obtained. The 24-h excretion of these acids is 0.01-0.1 mmol for healthy adults on a regular diet.Keywords
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