The Production of Capsules, Hyaluronic Acid and Hyaluronidase by 25 Strains of Group C Streptococci

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Abstract
A sensitive turbidimetric test enabled hyaluronidase to be detected in all but 3 of the 25 strains examined. These 3, and 6 of the hyaluronidase producers were heavily capsulated on serum glucose agar and in serum + glucose enriched liquid media. Testicular hyaluronidase readily destroyed the capsules. For the demonstration of hyaluronidase early sampling and continual neutralization are important. Non-capsulated varients resembled the parent strains in enzyme production. A single mouse passage did not qualitatively influence the production of capsules, hyaluronic acid or hyaluronidase.