Synthesis of Peptides with α,β‐Dehydroamino Acids, II. Synthesis of tert‐Butyloxycarbonyldipeptides of Dehydroalanine and Dehydrophenylalanine
- 13 May 1985
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 1985 (5) , 893-900
- https://doi.org/10.1002/jlac.198519850503
Abstract
Condensation of amides of Boc‐amino acids3) with pyruvic acid leads to Boc‐dipeptides 1 – 3 of dehydroalanine and 1‐Boc‐5‐alkyl‐2‐methyl‐4‐oxo‐2‐imidazolidinecarboxylic acids 8 – 10. The amides, however, do not condense with phenylpyruvic acid. Boc‐dipeptides of dehydroalanine (1 – 3) and dehydrophenylalanine (4 – 7) are synthesized using (Boc)2O and dehydrodipeptides with a free unmasked N‐terminal amino group.Keywords
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